Table 2.
Odds Ratios (95% Confidence Intervals) for Colorectal Cancer by Levels of Various Plasma B Vitamins
| Plasma Level (quartiles) | No. of Cases/ Controls |
Crude Model | Multivariate Model 1† | Multivariate Model 2‡ |
|---|---|---|---|---|
| Folate (ng/ml) | ||||
| ≤9.94 | 63/98 | 1.00 | 1.00 | NA |
| 9.95–15.3 | 54/97 | 0.87 (0.54–1.41) | 0.91 (0.56–1.49) | |
| 15.4–26.1 | 58/101 | 0.74 (0.42–1.30) | 0.79 (0.44–1.41) | |
| >26.1 | 48/111 | 0.56 (0.31–1.03) | 0.61 (0.33–1.13) | |
| p-value for trend§ | 0.055 | 0.097 | ||
| PLP (pmol/ml) | ||||
| ≤26.6 | 70/90 | 1.00 | 1.00 | 1.00 |
| 26.7–51.5 | 60/95 | 0.80 (0.49–1.32) | 0.84 (0.51–1.40) | 0.86 (0.52–1.45) |
| 51.6-10.1 | 52/105 | 0.57 (0.34–0.93) | 0.62 (0.37–1.03) | 0.65 (0.37–1.12) |
| >101 | 41/117 | 0.43 (0.26–0.71) | 0.49 (0.29–0.83) | 0.52 (0.29–0.92) |
| p-value for trend | 0.001 | 0.009 | 0.030 | |
| Vitamin B12 (pg/ml) | ||||
| ≤361 | 55/101 | 1.00 | 1.00 | 1.00 |
| 362–525 | 59/103 | 1.00 (0.63–1.58) | 1.13 (0.70–1.83) | 1.20 (0.73–1.97) |
| 526–722 | 50/107 | 0.80 (0.49–1.30) | 0.89 (0.54–1.46) | 1.00 (0.59–1.69) |
| >722 | 59/96 | 1.10 (0.69–1.76) | 1.33 (0.81–2.18) | 1.66 (0.97–2.86) |
| p-value for trend | 0.74 | 0.33 | 0.082 | |
| Methylmalonic acid (pmol/ml) | ||||
| ≤103 | 34/51 | 1.00 | 1.00 | 1.00 |
| 104–151 | 21/58 | 0.52 (0.26–1.07) | 0.47 (0.22–1.00) | 0.47 (0.22–1.01) |
| 152–213 | 30/54 | 1.01 (0.47–2.15) | 0.92 (0.41–2.03) | 0.92 (0.41–2.05) |
| >213 | 32/46 | 1.34 (0.59–3.04) | 1.25 (0.53–2.94) | 1.29 (0.54–3.06) |
| p-value for trend | 0.28 | 0.34 | 0.31 | |
| Homocysteine (nmol/ml) | ||||
| ≤7.65 | 55/106 | 1.00 | 1.00 | 1.00 |
| 7.66–9.44 | 61/101 | 1.17 (0.72–1.88) | 1.06 (0.65–1.72) | 1.01 (0.61–1.65) |
| 9.45–11.8 | 48/103 | 0.89 (0.53–1.51) | 0.76 (0.44–1.32) | 0.73 (0.42–1.26) |
| >11.8 | 59/96 | 1.21 (0.69–2.12) | 1.07 (0.60–1.90) | 1.00 (0.56–1.79) |
| p-value for trend | 0.62 | 0.87 | 0.96 | |
| Cysteine (nmol/ml) | ||||
| ≤235 | 32/52 | 1.00 | 1.00 | 1.00 |
| 236–259 | 34/49 | 0.91 (0.46–1.82) | 0.89 (0.44–1.80) | 0.91 (0.44–1.85) |
| 260–287 | 25/55 | 0.61 (0.28–1.33) | 0.58 (0.26–1.31) | 0.60 (0.27–1.35) |
| >287 | 27/55 | 0.55 (0.22–1.37) | 0.50 (0.20–1.30) | 0.55 (0.21–1.48) |
| p-value for trend | 0.15 | 0.12 | 0.17 |
*
Based on conditional logistic regression, using matched sets as strata. Cases and controls were matched on sex, ethnicity, study site, age at blood draw, fasting duration and date and time of blood draw. Continuous variables for age at blood draw and hours of fasting prior to blood draw were included as adjustment variables.
†
Further adjusted for: hours of moderate or vigorous physical activity, processed meat, pack-years, BMI, ethanol, family history of colorectal cancer, and history of colorectal cancer screening.
‡
Further adjusted for plasma folate.
§
Trend based on the median of each quartile.