Table 3.
Interactions of Alcohol, CRP and MTHFR C677T with Selected Plasma B-Vitamins in Relation to Risk of Colorectal Cancer
| Alcohol Intake ≤ 0.74 g/d | Alcohol Intake > 0.74 g/d | ||||
|---|---|---|---|---|---|
| Plasma Level (median) | No. of Cases/ Controls |
OR* (95% CI) | No. of Cases/ Controls |
OR (95% CI) | P for interaction |
| Folate (ng/ml) | |||||
| ≤ 15.3 | 56/85 | 1.00 | 61/110 | 0.86 (0.53–1.41) | |
| > 15.3 | 54/126 | 0.55 (0.31–0.95) | 52/86 | 0.97 (0.53–1.78) | 0.0497 |
| PLP (pmol/ml) | |||||
| ≤ 51.5 | 69/94 | 1.00 | 62/93 | 0.91 (0.56–1.46) | |
| > 51.5 | 41/119 | 0.43 (0.26–0.74) | 52/105 | 0.76 (0.44–1.31) | 0.072 |
| Vitamin B12 (pg/ml) | |||||
| ≤ 525 | 50/91 | 1.00 | 64/116 | 1.09 (0.67–1.76) | |
| > 525 | 60/122 | 0.90 (0.56–1.46) | 50/82 | 1.26 (0.73–2.17) | 0.46 |
| Methylmalonic Acid (pmol/ml) | |||||
| ≤ 151 | 26/46 | 1.00 | 29/63 | 0.80 (0.39–1.63) | |
| > 151 | 29/44 | 1.57 (0.69–3.55) | 33/56 | 1.24 (0.55–2.82) | 0.97 |
| Plasma CRP ≤ 0.80 mg/l | Plasma CRP > 0.80 mg/l | ||||
| Folate (ng/ml) | |||||
| ≤ 15.3 | 49/96 | 1.00 | 68/99 | 1.16 (0.69–1.97) | |
| > 15.3 | 59/133 | 0.77 (0.44–1.34) | 47/78 | 0.86 (0.47–1.58) | 0.93 |
| PLP (pmol/ml) | |||||
| ≤ 51.5 | 51/89 | 1.00 | 80/98 | 1.24 (0.76–2.00) | |
| > 51.5 | 57/140 | 0.69 (0.42–1.13) | 36/83 | 0.65 (0.37–1.15) | 0.42 |
| Vitamin B12 (pg/ml) | |||||
| ≤ 525 | 63/110 | 1.00 | 51/ 97 | 0.79 (0.48–1.30) | |
| > 525 | 45/119 | 0.71 (0.44–1.14) | 65/84 | 1.18 (0.73–1.91) | 0.027 |
| Methylmalonic Acid (pmol/ml) | |||||
| ≤ 151 | 24/56 | 1.00 | 31/53 | 1.25 (0.60–2.61) | |
| > 151 | 22/45 | 1.50 (0.67–3.35) | 40/55 | 1.93 (0.87–4.29) | 0.95 |
| MTHFR 677CC/CT | MTHFR 677TT | ||||
| Folate (ng/ml) | |||||
| ≤ 15.3 | 82/145 | 1.00 | 13/13 | 1.53 (0.62–3.81) | |
| > 15.3 | 92/168 | 0.92 (0.55–1.51) | 9/28 | 0.56 (0.23–1.35) | 0.15 |
| PLP (pmol/ml) | |||||
| ≤ 51.5 | 101/154 | 1.00 | 14/12 | 1.83 (0.75–4.47) | |
| > 51.5 | 74/163 | 0.74 (0.47–1.15) | 8/29 | 0.47 (0.20–1.09) | 0.078 |
| Vitamin B12 (pg/ml) | |||||
| ≤ 525 | 86/166 | 1.00 | 12/17 | 1.26 (0.57–2.79) | |
| > 525 | 91/151 | 1.27 (0.87–1.87) | 10/24 | 0.87 (0.37–2.04) | 0.28 |
| Methylmalonic Acid (pmol/ml) | |||||
| ≤ 151 | 39/76 | 1.00 | 7/10 | 1.16 (0.40–3.39) | |
| > 151 | 42/71 | 1.38 (0.66–2.91) | 6/8 | 1.20 (0.26–5.47) | 0.75 |
*
Based on conditional logistic regression, using matched sets as strata. Cases and controls were matched on sex, ethnicity, study site, age at blood draw, fasting duration and date and time of blood draw. Continuous variables for age at blood draw and hours of fasting prior to blood draw were included as adjustment variables, along with hours of moderate and vigorous physical activity, processed meat, pack-years, BMI, ethanol and family history of colorectal cancer, and history of colorectal cancer screening. MTHFR analyses did not adjust for family history of colorectal cancer.