Table 6. Inverse correlation between baseline values and changes after Tat immunization of immune activation markers and T-regs.
| ISS T-002 | n | Pearson correlation | p-value |
| coefficient | |||
| CD38+HLA-DR− on CD8+ T cells (%) | 38 | r = −0.5 | 0.0005 |
| CD38−HLA-DR+ on CD8+ T cells (%) | 38 | r = −0.5 | 0.0023 |
| CD38+HLA-DR+ on CD8+ T cells (%) | 38 | r = −0.4 | 0.0190 |
| CD38+ HLA-DR− on CD4+ T cells (%) | 37 | r = −0.3 | 0.0623 |
| HLA-DR+CD38− on CD4+ T cells (%) | 37 | r = −0.7 | <0.0001 |
| CD38+HLA-DR+ on CD4+T cells (%) | 37 | r = −0.8 | <0.0001 |
| β2-microglobulin (mg/L) | 77 | r = −0.3 | 0.0017 |
| Neopterin (nmol/L) | 77 | r = −0.9 | <0.0001 |
| Total IgM (mg/dL) | 77 | r = −0.1 | 0.5371 |
| Total IgG (mg/dL) | 77 | r = −0.4 | 0.0001 |
| Total IgA (mg/dL) | 77 | r = 0.0 | 0.7519 |
| CD25+ on CD4+ T cells (%) | 66 | r = −0.5 | <0.0001 |
| FOXP3+ on CD4+CD25+ T cells (%) | 60 | r = −0.5 | 0.0001 |
| CD25+FOXP3+ on CD4+ T cells (%) | 60 | r = −0.3 | 0.0171 |
The relationship between baseline values and changes at week 20 or week 24 for all immunized subjects was evaluated by the Pearson correlation coefficient (r) after cumulating both Tat doses. n indicates the number of individuals evaluated for each parameter.