Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Nov 11;6(11):e1000990. doi: 10.1371/journal.pcbi.1000990

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Thommen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

(A) Schematic representation of how window center and duration and , which characterize a coupling with rectangular gating profile, are estimated from the piPRC using Eq. (1). (B) piPRC characterizing the phase change induced by an infinitesimal perturbation of some parameters of the model (transcription an degradation kinetics). (C) Characterization of window center and duration satisfying Eq. (1) for the coupling mechanisms shown in (B), as illustrated in (A). Parameters chosen in (B) are modulated either positively (red) or negatively (blue). (D) Characterization of window center and duration of gated couplings which adjust experimental data with a RMS error below 10% for two different coupling strengths (see box on the right-hand side of the top: is the ratio between the parameter values within and outside the coupling window).

Inline graphic — (A) Schematic representation of how window center and duration and , which characterize a coupling with rectangular gating profile, are estimated from the piPRC using Eq. (1). (B) piPRC characterizing the phase change induced by an infinitesimal perturbation of some parameters of the model (transcription an degradation kinetics). (C) Characterization of window center and duration satisfying Eq. (1) for the coupling mechanisms shown in (B), as illustrated in (A). Parameters chosen in (B) are modulated either positively (red) or negatively (blue). (D) Characterization of window center and duration of gated couplings which adjust experimental data with a RMS error below 10% for two different coupling strengths (see box on the right-hand side of the top: is the ratio between the parameter values within and outside the coupling window).