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. 2010 Nov 11;6(11):e1000991. doi: 10.1371/journal.pcbi.1000991

Figure 4. Two of our accurate predictions were not implicated by previous quantitative genetics studies.

Figure 4

A chromosomal map of the laboratory mouse genome is shown, labeled with results compiled from previous human GWAS (red triangles) and mouse QTL studies (blue lines) of bone mineral density (BMD) [5]. Due to the limited resolution of some QTL studies, 83% of the mouse genome lies underneath the 95% confidence interval of at least one QTL. We experimentally confirmed two of our most confident predictions for bone defects that were not implicated in any previous QTL or GWAS effort: Timp2 and Abcg8 (green arrows). While Abcg8 falls underneath a single QTL on chromosome 17, it was not a candidate gene for the loci as there are no polymorphisms within 20kb of Abcg8 in the strains crossed for this study [39]. Timp2 does not lie under any previously implicated loci.