Figure 5. Predicting novel candidates associated with bone phenotypes.

Precision-recall curves of the cross-validation results for A. “abnormal bone density” (MP:0005007) and B. “abnormal bone structure” (MP:0003795). For both phenotypes, our network-based SVM achieved a better performance than summed weight. C. A network view of functional relationships centered around Timp2 and Abcg8. Nodes indicate genes, and the thickness of lines indicates relationship confidence. Both Timp2 and Abcg8 are connected to several genes that demonstrate a bone mineralization phenotype or are otherwise implicated in osteoporosis. Networks were visualized using VisANT [50].