Figure 4. Morphological analysis of tongue reveals PrP^Sc deposition in nerve fibers and myocytes.

A) Histological analysis of tongue from the clinical, vCJD infected macaque shows muscle fibers intermingled with peripheral nerves (Haematoxilin and Eosin staining, scale bar 50 µm). B, C) PET blot (consecutive section from A) showing labelling of PrP^Sc. Higher magnification (C) of the insert shown in (B) revealed PrP^Sc staining of longitudinal nerve fibers (arrow) and adjacent myocytes (triangles).