Figure 5.

Compound 31,345 self-administration substitution tests and 31,345-triggered reinstatement of drug-seeking behavior. (a) Representative records of cocaine (0.5 mg/kg per infusion) or 31,345 (0.5 mg/kg per infusion) self-administration over a span of seven consecutive daily replacement tests. Arrows indicate end of session. (b) Mean self-administration rate during cocaine, 31,345, or vehicle self-administration testing. (c) 31,345 (1, 3 or 10 mg/kg, i.p.)-induced reinstatement of drug-seeking behavior. ^*p<0.05, ^***p<0.001, compared with the last day of cocaine self-administration in b or vehicle (0 mg/kg 31,345) in c. ^###p<0.001, compared with the last day of 31,345 self-administration testing.