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Model to explain drug resistance and dependence. PtxR, paclitaxel resistant mutant; PtxD, paclitaxel dependent mutant; CmdR, colcemid resistant mutant; CmdD, colcemid dependent mutant; [Cmd] or [Ptx], drug concentration. Dashed vertical lines, boundaries between normal proliferation and toxicity (defects in mitosis and cell division).
