Table 3. Peak Post-Drug Subjective and Physiological Responses during Sampling Sessionsa.
| Measure (range of scores)b |
SR-AMP 0 mg/day (placebo) |
SR-AMP 30 mg/day |
SR-AMP 60 mg/day |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pla | Hyd | Coc | Coc+Hyd | Pla | Hyd | Coc | Coc+Hyd | Pla | Hyd | Coc | Coc+Hyd | |
| Stimulant-sensitive adjective rating scale (0–84)COC+, HYD+, AMP– | 2.3 (1.0) | 8.6 (2.4) | 13.4 (4.6) | 17.6 (4.5) | 1.5 (0.8) | 6.3 (2.3) | 7.8 (3.0) | 10.8 (3.4) | 0.9 (0.5) | 6.1 (2.4) | 7.3 (2.4) | 12.9 (3.5) |
| Cocaine craving questionnaire (10–70)COC+, HYD+ | 23.8 (5.2) | 27.1 (4.1) | 39.3 (4.3) | 38.9 (4.7) | 18.6 (3.7) | 23.1 (5.2) | 22.1 (5.5) | 31.4 (6.4) | 18.0 (3.6) | 19.4 (3.8) | 27.8 (5.9) | 40.1 (9.2) |
| Heroin craving questionnaire (10–70)COC+, AMP– | 38.5 (6.7) | 41.5 (6.4) | 44.5 (7.2) | 46.0 (5.9) | 34.5 (5.8) | 42.4 (5.8) | 39.4 (7.0) | 40.5 (5.6) | 27.0 (5.4) | 35.4 (5.1) | 31.8 (6.2) | 33.3 (5.4) |
| Opioid withdrawal scale (0–64) | 2.6 (0.8) | 2.3 (0.9) | 4.8 (1.7) | 5.5 (1.9) | 1.9 (0.9) | 1.3 (0.9) | 4.0 (1.8) | 2.5 (1.4) | 1.4 (0.6) | 1.5 (0.9) | 2.8 (0.9) | 3.1 (1.2) |
| Opioid agonist scale (0–64)HYD+ | 7.8 (1.3) | 17.0 (2.6) | 10.8 (2.3) | 17.3 (2.7) | 7.4 (0.9) | 16.5 (1.7) | 9.8 (1.9) | 16.3 (1.3) | 7.0 (0.9) | 14.6 (1.8) | 8.1 (1.1) | 17.4 (2.1) |
| Any drug effect VAS (0–100)COC+, HYD+, COC × HYD, AMP– | 5.1 (2.5) | 67.0 (10.2) | 50.8 (10.1) | 79.8 (5.5) | 7.9 (6.6) | 59.5 (8.4) | 29.8 (7.4) | 65.3 (7.5) | 1.4 (0.7) | 47.9 (9.1) | 29.5 (6.9) | 62.5 (9.2) |
| Good drug effect VAS (0–100)COC+, HYD+, COC × HYD, AMP– | 6.1 (2.7) | 74.9 (6.5) | 49.9 (12.1) | 75.9 (6.5) | 4.4 (3.2) | 62.0 (8.4) | 24.3 (8.5) | 70.9 (5.6) | 1.8 (0.7) | 52.8 (8.9) | 22.6 (6.9) | 70.4 (7.3) |
| Bad drug effect VAS (0–100) HYD– | 28.6 (15.5) | 12.8 (6.7) | 19.8 (9.5) | 10.8 (4.5) | 7.3 (6.3) | 16.3 (12.1) | 25.0 (11.5) | 3.8 (2.4) | 1.4 (0.6) | 2.5 (0.9) | 13.1 (8.1) | 9.5 (4.4) |
| Drug high VAS (0–100)COC+, HYD+, AMP–, AMP × COC | 5.1 (2.4) | 64.5 (10.1) | 51.3 (10.2) | 76.3 (6.3) | 4.9 (3.7) | 54.4 (10.2) | 20.6 (7.2) | 63.5 (8.1) | 1.4 (0.7) | 47.6 (10.1) | 21.8 (6.3) | 62.1 (10.9) |
| Drug liking VAS (0–100)COC+, HYD+, AMP– | 11.6 (5.7) | 73.4 (5.4) | 47.8 (11.2) | 77.6 (7.1) | 6.0 (3.2) | 62.4 (7.2) | 20.0 (6.0) | 69.0 (5.7) | 4.4 (2.6) | 53.8 (9.0) | 23.5 (6.5) | 70.6 (7.5) |
| Stimulated VAS (0–100)COC+, HYD+, AMP– | 5.6 (2.6) | 33.0 (13.1) | 49.9 (11.1) | 65.9 (13.1) | 2.5 (1.4) | 23.0 (10.7) | 22.0 (8.3) | 47.3 (9.4) | 1.9 (0.8) | 21.8 (10.0) | 22.0 (7.5) | 36.6 (11.5) |
| Sedated VAS (0–100)HYD+, AMP × COC, AMP × COC × HYD | 3.4 (1.3) | 49.4 (12.8) | 4.4 (1.6) | 12.9 (4.2) | 7.3 (6.3) | 41.3 (11.8) | 4.6 (2.1) | 31.0 (11.3) | 2.1 (0.8) | 33.0 (12.6) | 6.6 (5.5) | 38.5 (13.1) |
| Want drug again VAS (0–100)COC+, HYD+, AMP– | 24.3 (12.2) | 64.9 (7.3) | 51.9 (12.3) | 75.0 (8.2) | 6.1 (3.5) | 46.9 (10.0) | 15.0 (5.7) | 61.6 (6.3) | 2.3 (0.8) | 48.9 (11.6) | 14.9 (6.2) | 56.8 (10.8) |
| ARCI MBG scale (0–16)COC+, HYD+ | 3.0 (0.9) | 6.6 (1.6) | 5.0 (1.4) | 7.4 (1.4) | 2.9 (0.9) | 5.4 (1.5) | 3.4 (0.9) | 6.9 (1.3) | 2.9 (0.8) | 7.1 (1.7) | 3.0 (0.9) | 6.5 (1.5) |
| ARCI BG scale (0–13)AMP × COC | 6.6 (0.7) | 6.4 (0.5) | 7.4 (0.9) | 8.5 (0.7) | 7.0 (0.9) | 6.8 (0.7) | 6.9 (0.7) | 7.3 (0.9) | 7.4 (0.8) | 7.4 (0.9) | 7.0 (0.8) | 7.5 (1.0) |
| ARCI A scale (0–11)COC+, HYD+ | 2.9 (0.5) | 4.8 (0.6) | 4.8 (0.8) | 6.0 (0.7) | 3.0 (0.7) | 4.3 (0.8) | 3.6 (0.8) | 4.9 (1.0) | 3.4 (0.7) | 5.3 (1.2) | 3.8 (0.8) | 5.6 (1.1) |
| ARCI PCAG scale (0–15) COC × HYD | 3.8 (0.3) | 6.4 (0.8) | 4.4 (0.5) | 4.9 (0.5) | 4.8 (0.9) | 4.4 (0.6) | 5.1 (0.6) | 4.9 (0.7) | 3.6 (0.3) | 4.5 (0.5) | 4.9 (1.1) | 5.3 (0.7) |
| ARCI LSD scale (0–14)COC+ | 4.1 (0.8) | 4.4 (0.9) | 6.9 (1.4) | 6.5 (1.2) | 3.9 (0.4) | 3.5 (0.8) | 5.8 (1.3) | 4.5 (0.9) | 3.1 (0.3) | 3.5 (1.1) | 6.4 (1.0) | 5.6 (1.3) |
| MCP drug value (US$)COC+, HYD+ | 0.29 (0.29) | 9.64 (1.78) | 9.36 (2.63) | 13.07 (3.24) | 0.29 (0.29) | 10.25 (2.93) | 5.38 (3.68) | 14.79 (3.82) | 0.29 (0.29) | 11.07 (3.22) | 1.93 (0.93) | 11.79 (3.58) |
| Respiration rate (b.p.m.)HYD– | 13.6 (0.7) | 12.5 (0.7) | 13.9 (0.6) | 14.3 (1.0) | 13.6 (0.5) | 12.4 (0.7) | 13.6 (0.8) | 12.1 (0.6) | 13.5 (0.5) | 12.1 (0.8) | 13.5 (0.6) | 12.9 (0.6) |
| Oxygen saturation (%)HYD– | 96.9 (0.5) | 94.5 (0.7) | 97.0 (0.3) | 95.1 (0.5) | 96.4 (0.5) | 94.9 (0.4) | 96.6 (0.6) | 95.0 (0.6) | 96.4 (0.5) | 94.8 (0.6) | 97.0 (0.4) | 94.5 (0.6) |
| Heart rate (b.p.m.)COC+, AMP–, AMP × COC, AMP × HYD | 72.4 (4.7) | 73.0 (3.8) | 90.6 (4.1) | 96.8 (6.7) | 81.4 (2.9) | 80.0 (3.1) | 87.5 (5.2) | 90.8 (4.6) | 82.0 (3.2) | 90.1 (3.8) | 87.8 (3.6) | 94.6 (4.3) |
| Systolic BP (mm Hg)COC+, AMP × COC | 113.3 (4.2) | 118.0 (5.0) | 130.0 (6.0) | 131.4 (7.0) | 118.4 (5.9) | 119.1 (5.7) | 123.4 (4.5) | 123.4 (6.3) | 125.4 (5.1) | 119.5 (6.8) | 126.9 (4.7) | 125.6 (6.0) |
| Diastolic BP (mm Hg)COC+, AMP × COC | 67.5 (1.7) | 71.6 (2.7) | 80.3 (3.2) | 82.5 (3.7) | 75.0 (3.2) | 75.3 (4.0) | 77.9 (2.5) | 77.8 (4.1) | 78.0 (2.9) | 74.6 (4.1) | 79.6 (3.0) | 80.3 (3.6) |
a
Sample means (±1 SEM), n=8, except for drug value (n=7).
b
AMP, COC, and HYD indicates significant main effects for d-amphetamine (AMP), cocaine (COC), or hydromorphone (HYD) or interaction (eg, COC × HYD) based on overall ANOVA. Also indicated is whether the drug significantly increased scores (+) or significantly decreased scores (–). See Table 4 for ANOVA statistical details.