TABLE 3.
Clinical characteristics and UPDRS-III total and subscores of LRRK2 G2019S carriers and matched controls*
| Subject | Sex (n) |
Family history** |
Follow up time (yrs) |
UPDRS-III at First Exam | UPDRS-III at Last Exam | Meets PD criteria |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age (yrs) |
Total score |
RT | R | B | P/G | Age (yrs) |
Total score |
RT | R | B | P/G | |||||
| 1 | M | + | 5.67 | 78 | 1 | 0 | 0 | 0 | 1 | 84 | 5 | 0 | 0 | 0 | 5 | No |
| Controls-1 | M(5) | 6.1±0.9 | 76.9±2.9 | 3.2 (2-6) | 0 | 0 | 0.4 (0,2) | 2.5 (2,4) | 82.9±3.3 | 8 (2,16) | 0 | 0.2 (0,1) | 3.4 (0,8) | 4 (2,8) | No | |
| 2 | F | + | 8.28 | 86 | 8 | 0 | 0 | 0 | 7 | 95 | 29 | 0 | 5 | 16 | 7 | Yes |
| Controls-2 | F(5) | 5.4±1.8 | 84.2±1.1 | 5 | 0 | 0 | 2 | 2 (1,3) | 89.6±1.0 | 7.5 (1,11) | 0 | 0 | 5.2 (0,10) | 3.25 (1,8) | No | |
| 3 | F | + | 7.33 | 81 | 6 | 0 | 0 | 2 | 4 | 88 | 14 | 0 | 0 | 6 | 6 | No |
| Controls-3 | F(5) | 7.0±0.2 | 81.1±3.0 | 2.4 (1,6) | 0 | 0 | 0 | 2.4 (1,6) | 88.1±3.0 | 7.2 (3,18) | 0.2 (0,1) | 0 | 4.4 (0,9) | 2.4 (0,9) | No | |
| 4 | F | - | 4.31 | 72 | 1 | 0 | 0 | 0 | 1 | 77 | 1 | 0 | 0 | 1 | 0 | No |
| Controls-4 | F(5) | 4.0±0.1 | 72.3±2.7 | 1.6 (1,3) | 0 | 0 | 0 | 1.2 (1,2) | 76.3±2.6 | 2.4 (0,7) | 0 | 0 | 0.6 (0,2) | 1 (0,5) | No | |
| 5 | F | - | 3.9 | 90 | 19 | 0 | 2 | 11 | 6 | 94 | 25 | 0 | 0 | 15 | 10 | No |
| Controls-5 | F(5) | 2.6±0.5 | 86.9±1.4 | 8.2 (2,30) | 0 | 0.6 (0,2) | 3.6 (0,16) | 4 (1,12) | 89.6±1.7 | 12 (1,27) | 0 | 0 | 5.8 (0,12) | 5.8 (1,15) | No | |
| 6 | F | - | 0 | 85 | 2 | 0 | 0 | 1 | 1 | - | - | - | - | - | - | No |
| Controls-6 | F(5) | 2.7±0.5 | 83.3±2.7 | 6.6 (1,20) | 0 | 0 | 3.6 (0,14) | 1.8 (1,4) | 86.1±2.3 | 9.6 (5,15) | 0 | 1.2 (0,4) | 4.4 (0,8) | 3.6 (1,7) | No | |
*
UPDRS-III: Unified Parkinson's Disease Rating Scale, Motor Subscale; RT: Rest tremor component of UPDRS-III; R: Rigidity component of UPDRS-III; B: bradykinesia component of UPDRS-III, not including speech and facial expression; P/G: postural changes and gait component of UPDRS-III. Years of follow up and age are expressed in mean years ± S.D. UPDRS and subscores are expressed in mean points and range.
**
Subjects 1-2 had a family history of Parkinson's disease in first-degree relatives. Subject 6's mother carried a diagnosis of Pick's disease.