Fig. 7.

STAT3 is important for infarct size reduction by ischemic postconditioning, but not for pharmacological postconditioning with cyclosporine A (CsA). a Infarct size (in % of the area at risk) was determined in WT and STAT3-KO mice undergoing 30 min ischemia and 120 min reperfusion. 10 mg/kg CsA or 0.9% NaCl solution were administered intravenously 5 min before reperfusion, *p < 0.05. b Historic data [2] showing that ischemic postconditioning by 3 cycles of 10 s ischemia and reperfusion each at the onset of reperfusion reduced infarct size after 30 min ischemia and 120 min reperfusion in WT, but not in STAT3-KO mice, *p < 0.05