Table 5.

Affinity and selectivity studies of ¹²⁴I-3 to EGFR

			EGF-R L858R	EGF-R T790M	EGF-R T790M/L858R	EGF-R wt	ERBB2	IGF1-R	KIT	PDGFR-alpha	PDGFR-beta	TIE2	VEGF-R1	VEGF-R2	VEGF-R3
Compound ID	Plate ID	Well ID	IC50 (M)	IC50 (M)	IC50 (M)	IC50 (M)	IC50 (M)	IC50 (M)	IC50 (M)	IC50 (M)	IC50 (M)	IC50 (M)	IC50 (M)	IC50 (M)	IC50 (M)
Iodo-Peg(3)	3854-HAD-02	A2	<3E−09	2.47E−08	4.66E−08	<3E−09	8.28E−09	>1E−04	>1E−04	1.35E−05	6.34E−06	7.17E−06	>1E−04	3.10E−06	1.07E−05
Iodo-Peg(3)	3854-HAD-02	B2	<3E−09	1.66E−08	4.24E−08	<3E−09	3.42E−09	>1E−04	>1E−04	8.31E−06	5.29E−06	6.86E−06	>1E−04	2.49E−06	6.96E−06
Iodo-Peg(3)	3854-HAD-02	C2	<3E−09	8.53E−09	1.92E−08	<3E−09	<3E−09	>1E−04	>1E−04	8.40E−06	4.58E−06	3.27E−06	>1E−04	2.05E−06	5.18E−06