Figure 1.

Generation and characterization of FGF-8b transgenic mice. (A) The transgene construct. (B) Transgene expression was localized to VP of TG mice by in situ hybridization with FGF-8b-specific riboprobes (a, b) and by FGF-8b immunostaining (c, d). Expression of FGF-8b was absent or low in VP samples of WT mice. (C) Representative pictures of prostate blocks from a 13.5-month-old WT and a 14-month-old FGF-8b TG mouse showing the abnormal, cystic appearance of TG mouse prostate. Bl indicates bladder; LP, lateral prostate; SV, seminal vesicle.