Figure 1.

An Abridged Pedigree of an American Family with Recessively Inherited PCARP

A genome scan established linkage between PCARP and loci on chromosome 1q (AXPC1). To the left of each individual in each generation are seven chromosome 1q loci. Below each individual are reconstructed haplotypes for these loci. A star indicates a lack of homozygosity in affected individuals 14, 18, and 23 for locus D1S249 and in individual 30 for locus D1S2141. Consanguineous marriages have calculated inbreeding coefficients over the bar uniting individuals. Black circles (females) and squares represent affected individuals with PCARP (n = 6). Three-quarters shading represents infants with areflexia and early retinal dystrophy (n = 3). Obligate heterozygotes are represented by symbols that are half shaded (n = 10). Dark bars show parental haplotypes that segregate with PCARP. The figure is reprinted with permission from Lippincott Williams & Wilkins.²