Skip to main content
. 2010 Nov 12;87(5):643–654. doi: 10.1016/j.ajhg.2010.10.013

Figure 4.

Figure 4

Mutated FLVCR1 Amino Acid Residues in PCARP

(A) Evolutionary conservation of FLVCR1 mutated residues and surrounding amino acids. FLVCR1 encodes a cell-surface protein predicted to contain 555 amino acids, 12 transmembrane-spanning segments (TM1–TM5 and part of TM6 are underlined), and six extracellular loops (ECL 1–3 are shown). The amino acid residues mutated in PCARP (p.Asn121Asp, p.Cys192Arg, and p.Ala241Thr), shown in gray and bold, are all are located in transmembrane segments. Homo sapiens, man; Pan troglodytes, chimpanzee; Canis lupus familiaris, dog; Bos taurus, domestic cow; Mus musculus, house mouse; Gallus gallus, chicken; Danio rerio, zebrafish.

(B) Partial FLVCR structure based on UniProt Knowledgebase predictions showing the location of the mutated residues within the transmembrane segments.