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. Author manuscript; available in PMC: 2010 Nov 12.
Published in final edited form as: Transplantation. 1999 Sep 27;68(6):747–757. doi: 10.1097/00007890-199909270-00006

Figure 9.

Figure 9

IL-2 synthesis detected by immunohistochemical staining in the spleen of heart allograft recipients, at various times post heart transplant (HTX). Whereas infusion of donor mature DC 7 days before HTX was associated with high levels of IL-2 expression (blue staining) on day 0, 7, and 14 posttransplant, animals given immature donor DC did not exhibit strong staining for IL-2 until 7 days post-HTX. Infusion of immature donor DC+anti-CD40L mAb suppressed IL-2 production at each time point examined. Magnification ×100.