Table 3.
[3H]-thymidine incorporation in kidney and small intestine from normal, nephrectomized, or small intestine–resected rats treated or not treated for 4 preoperative days with rapamycin (0.3 mg/kg/day i.m.)
| Group | n | Treatment | Surgery | DNA synthesis (×103/c.p.m./mgDNA) | P |
|---|---|---|---|---|---|
| 6 | 5 | Vehicle | No | 2.4±0.2 | — |
| 7 | 5 | Vehicle | Unilateral nephrectomy | 3.8±2.3 | — |
| 8 | 5 | RPM | Unilateral nephrectomy | 0.5±0.01 | <0.0005 vs. 7 |
| 9 | 5 | Vehicle | No | 17.2±2.3 | |
| 10 | 5 | Vehicle | 40% Small-intestine resection | 62.3±10.4 | |
| 11 | 5 | RPM | 40% Small-intestine resection | 29.3±5.1 | <0.05 vs. 10 |