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. Author manuscript; available in PMC: 2010 Nov 12.
Published in final edited form as: Pigment Cell Melanoma Res. 2010 Jan 22;23(2):225–237. doi: 10.1111/j.1755-148X.2010.00667.x

Figure 2.

Figure 2

Sequence of the proximal human MET promoter and reporter construct. (A) The MET promoter segment contains the 297 base pairs directly 5′ directly upstream and 28 bases directly 3′ of the MET gene transcriptional start site. The previously described PAX and MITF sites are highlighted with boxes. A putative SOX site is underlined with a dotted line. The transcriptional start site is marked with an arrow. (B) Schematic of the MET promoter reporter construct. The sequence shown in (A) corresponds with the DNA segment contained in the MET promoter luciferase reporter construct utilized in Figures 3, 4, and 5. The PAX (P), SOX (S), and MITF (M) sites, transcriptional start site (arrow) and luciferase reporter gene cassette are shown in diagram form.