Table 3.
Odds ratios (95% CI) of ovarian cancer by tertiles of CRP
| Tertiles CRP (mg/l)a | 1 | 2 | 3 | p-trend* |
|---|---|---|---|---|
| NSHDS, Sweden | <0.84 | 0.85–2.06 | ≥2.07 | |
| NYUWHS, USA | <1.17 | 1.18–2.94 | ≥2.95 | |
| Ordet, Italy | <0.91 | 0.92–1.96 | ≥1.97 | |
| All cases | ||||
| Cases/controls | 80/138 | 77/145 | 80/144 | |
| OR (95% CI) | 1.00 | 0.97 (0.64–1.47) | 1.15 (0.74–1.79) | 0.54 |
| Invasive cases | ||||
| Cases/controls | 70/117 | 68/130 | 69/126 | |
| OR (95% CI) | 1.00 | 0.90 (0.58–1.40) | 1.05 (0.65–1.69) | 0.85 |
| Invasive cases, NSHDS | ||||
| Cases/controls | 38/59 | 38/72 | 33/64 | |
| OR (95% CI) | 1.00 | 0.81 (0.45–1.47) | 0.83 (0.42–1.62) | 0.56 |
| Invasive cases, NYUWHS | ||||
| Cases/controls | 19/33 | 16/33 | 23/33 | |
| OR (95% CI) | 1.00 | 1.13 (0.47–2.71) | 1.88 (0.66–5.38) | 0.25 |
| Invasive cases, ORDET | ||||
| Cases/controls | 13/25 | 14/25 | 13/29 | |
| OR (95% CI) | 1.00 | 1.19 (0.38–3.72) | 1.17 (0.44–3.09) | 0.77 |
| Borderline cases | ||||
| Cases/controls | 10/21 | 9/15 | 11/18 | |
| OR (95% CI) | 1.00 | 1.64 (0.44–6.06) | 1.88 (0.47–7.53) | 0.37 |
| Serous cases | ||||
| Cases/controls | 44/77 | 39/77 | 50/82 | |
| OR (95% CI) | 1.00 | 0.98 (0.56–1.71) | 1.36 (0.76–2.44) | 0.29 |
| Invasive serous cases | ||||
| Cases/controls | 34/59 | 34/67 | 41/68 | |
| OR (95% CI) | 1.00 | 0.93 (0.51–1.73) | 1.23 (0.63–2.39) | 0.53 |
| Mucinous cases | ||||
| Cases/controls | 9/17 | 8/21 | 12/15 | |
| OR (95% CI) | 1.00 | 1.32 (0.31–5.55) | 6.29 (0.77–51.49) | 0.09 |
| Invasive mucinous cases | ||||
| Cases/controls | 9/14 | 4/16 | 10/11 | |
| OR (95% CI) | 1.00 | 0.63 (0.13–3.00) | 3.75 (0.29–48.63) | 0.42 |
| Endometrioid cases | ||||
| Cases/controls | 13/19 | 13/15 | 3/18 | |
| OR (95% CI) | 1.00 | 0.91 (0.25–3.27) | 0.23 (0.05–1.11) | 0.07 |
| Premenopausal cases | ||||
| Cases/controls | 41/67 | 27/51 | 20/39 | |
| OR (95% CI) | 1.00 | 0.95 (0.50–1.18) | 0.99 (0.46–2.15) | 0.96 |
| Postmenopausal cases | ||||
| Cases/controls | 36/67 | 49/91 | 58/102 | |
| OR (95% CI) | 1.00 | 1.06 (0.60–1.88) | 1.27 (0.72–2.32) | 0.41 |
| Lag >two years | ||||
| Cases/controls | 71/120 | 67/125 | 64/117 | |
| OR (95% CI) | 1.00 | 0.95 (0.61–1.48) | 1.09 (0.67–1.76) | 0.74 |
| Lag >five years | ||||
| Cases/controls | 54/93 | 42/95 | 48/74 | |
| OR (95% CI) | 1.00 | 0.81 (0.49–1.36) | 1.34 (0.76–2.35) | 0.38 |
All models from conditional logistic regression with adjustment for BMI
a
Cohort-specific tertiles based on CRP distribution among controls was used
*
p-value for linear trend over the tertiles, giving quantitative scores to all levels (1, 2, and 3)