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Chronic expression of SV2A-EGFP or SV2B-EGFP, but not SVOP-EGFP, restores synaptic depression in autaptic hippocampal neurons. Autaptic hippocampal neurons were infected with Lenti virions encoding the indicated protein 1–2 days after plating. Synaptic responses to stimulus trains were measured 11–16 days later. Neurons expressing SV2A-EGFP or SV2B-EGFP showed synaptic depression, whereas neurons expressing the related protein SVOP-EGFP did not.
