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. 2010 Sep 1;299(5):C1171–C1179. doi: 10.1152/ajpcell.00514.2009

Fig. 3.

Fig. 3.

Inhibition of AMPK or ATM prevents serum starvation-related increase in insulin-stimulated glucose transport. A: differentiated cells were incubated in serum-free medium in the presence or absence of 20 μM compound C (comp C) for 3 h. They were further incubated in HEPES-buffered saline (HBS) containing 5 mM nonradiolabeled d-glucose in the presence or absence of 100 nM insulin for 20 min before glucose transport assay (n = 18/group). B: differentiated cells were incubated in serum-free medium in the presence or absence of 1 μM KU55933 for 3 h. They were further incubated in HBS containing 5 mM nonradiolabeled d-glucose in the presence or absence of 100 nM insulin for 20 min before glucose transport assay (n = 12/group). 2DG, 2-deoxy-d-glucose. Data represent means ± SE. *Significant difference from corresponding control not treated with insulin (P < 0.05); †significant inhibition of the insulin effects by the inhibitors.