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Top: pseudo linescan of a synoviocyte loaded with the calcium indicator fluo-4 (see materials and methods); shown are the effects of increasing external K+ concentration for 5 s (indicated by the black bar) before and in the presence of 1 μM nifedipine. Bottom: F/F0 plot of the same experiment. Depolarization of the membrane with high potassium caused a large increase in intracellular calcium, and this effect was greatly attenuated in the presence of nifedipine.
