Fig. 6.

9-Phenanthrol dilates pressurized cerebral arteries. A: representative recoding of luminal diameter of a cerebral artery pressurized to 70 mmHg demonstrating the reversible effects of 9-phenanthrol (30 μM) on myogenic tone. B: summary data of myogenic tone for pressurized cerebral arteries (70 mmHg) under control conditions, following treatment with 9-phenanthrol (30 μM), and after the compound was washed out of the superfusion bath; n = 4. C: concentration response curve for the effects of 9-phenanthrol on cerebral artery myogenic tone. IC₅₀ = 2.6 μM; n = 4–7 arteries at each concentration. D: summary data showing the effects of 9-phenanthrol on KCl (60 mM)-induced constriction of cerebral arteries; n = 4. *P ≤ 0.05 vs. all other groups.