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Human breast cancer resistance protein (BCRP) topology and sequence alignment. A: the topology structure of human BCRP with 6 transmembrane (TM) α-helices deduced from experimental determination (30). B: human BCRP amino acid sequences in the predicted TM1 and TM6 (underlined) were aligned with the corresponding sequences of BCRP homologs and orthologs using Clustal W.
