TABLE V.

Fate of six patients who received liver replacement for indication of hepatoma and lived long enough after operation to permit observations about course of malignancy

Patient number	Metastases first detected (days postop.)	Location first metastases	Treatment of metastases	Metastases to homograft	Organs ultimately involved	Cause of death and time
OT 8	90	Lungs	Vincristine sulfate; 5 FU; surgical excision of intra-abdominal masses; local X-ray therapy to pelvis	Yes	Brain, lungs, liver other abdominal organs	Carcinomatosis, 400 days
OT 14	380	Diaphragm, liver, retroperitoneal space	—	Yes	Mediastinum, pleural cavity, diaphragm, retroperitoneal space, liver, pancreas, other abdominal organs	Carcinomatosis; disrupted cholecystoduodenostomy, 432 days*
OT 15	60	Lungs	—	Yes	Lungs, liver, diaphragm	Carcinomatosis, 339 days
OT 23	29	Lungs	—	Yes	Brain, lungs, liver, retroperitoneal space	Carcinomatosis, 143 days
OT 26	59	Lungs	—	No	Lungs	Gastrointestinal hemorrhage, 76 days
OT 33**	—	None found	—	No	None	Alive, 18 months

^*Retransplantation had been carried out at 380 days, at which time the first metastases were discovered. By the time of death 52 days later, the extension of the metastases was pronounced.

^**The diagnosis was an incidental finding in the liver specimen which had been removed because of biliary atresia.