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Changes in plasma BNP (A), plasma cGMP (B), plasma renin activity (C), and plasma aldosterone (D) with TLV, TLV+BNP, and BNP (A). P-value in box is from ANOVA for comparison of groups. *p<0.05 between groups. #p<0.05 vs. respective baseline. BNP, B-type natriuretic peptide, cGMP, cyclic guanosine monophosphate, PRA, plasma renin activity, TLV, tolvaptan. Data is median (interquartile range) except for (B), which is mean (standard deviation).
