Table 2.
Effects of NMDA treatment (10 mg·kg−1·day−1) for 4 days in rats
| Basal | NMDA (4 days) | P Value | |
|---|---|---|---|
| Urine volume, ml/day | 8 ± 1.5 | 30 ± 3.7 | P < 0.05 |
| Serum calcium, mg/dl | 11.42 ± 0.07 | 9.87 ± 0.13 | P < 0.05 |
| Serum P, mg/dl | 9.48 ± 0.39 | 9.41 ± 0.35 | NS |
| Serum Na, mEq/l | 138 ± 0.5 | 140 ± 0.2 | NS |
| Creatinine clearance, ml/min | 1.48 ± 0.12 | 1.11 ± 0.08 | P < 0.05 |
| Urinary excretion of Ca, mg/day | 4.8 ± 1.57 | 1.2 ± 0.17 | P < 0.05 |
| Urinary excretion of P, mg/day | 2.04 ± 0.91 | 19.6 ± 1.43 | P < 0.05 |
| Urinary excretion of Na, mEq/day | 0.45 ± 0.11 | 1.2 ± 0.14 | P < 0.05 |
| Osmolarity, mOsm/kg | 1,440 ± 192 | 396 ± 40 | P < 0.05 |
| Collagen type I fragments, ng/day | 3,127 ± 786 | 8,022 ± 156 | P < 0.05 |
| Osteocalcin, ng/ml | 98.4 ± 106 | 178.2 ± 135 | P < 0.05 |
Values are means ± SE; n = 10. P, phosphorous; Na, sodium; NS, not significant.