Fig. 1.

Ketogenic diet (KD) causes hepatic insulin resistance in mice. A: euglycemia (100–120 mg/dl) was maintained throughout the clamp in mice fed KD and those fed regular chow (RC). B: basal endogenous glucose production was similar between groups. C: glucose infusion rates were significantly lower in KD-fed mice. D: ability of insulin to suppress clamp endogenous glucose production was significantly impaired in KD-fed mice. E and F: glycolysis and glycogen synthesis were similar between groups. Values are means ± SE (n = 9 per group). **P < 0.01; ***P < 0.001 vs. RC.