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Subcellular analyses of activated cAMP response element-binding protein (CREB). A: semiquantitative analyses of the β-cell nuclear signal for phospho-CREB (p-CREB) shows a strong trend toward reduced immunoreactivity among β-cells of CVX rats. Typical sections from sham (B) and CVX (C) rats demonstrate decreased nuclear p-CREB levels in CVX rats. β-Cell area is outlined. *Bright bodies are autofluorescing erythrocytes. Scale bar, 50 μm.
