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. 1989 Sep;86(18):7260–7264. doi: 10.1073/pnas.86.18.7260

Changes in brain gene expression shared by scrapie and Alzheimer disease.

J R Duguid 1, C W Bohmont 1, N G Liu 1, W W Tourtellotte 1
PMCID: PMC298037  PMID: 2780570

Abstract

We have isolated two recombinant cDNAs whose corresponding RNAs have an increased abundance in scrapie-infected hamster brain. DNA sequence analysis has shown that these two recombinants represent the genes for sulfated glycoprotein 2 and transferrin. The abundance of sulfated glycoprotein 2 RNA is increased in hippocampus from patients with Alzheimer disease and Pick disease, whereas transferrin RNA is not strongly modulated in these conditions. Expression of two previously identified scrapie-modulated genes, encoding glial fibrillary acidic protein and metallothionein, is also increased in both of these neurodegenerative diseases.

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Selected References

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