Fig. 2.

Data from healthy controls (Control; n = 8), MS patients without internuclear opthalmoparesis (MS-Control; n = 8), and MS patients diagnosed with internuclear ophthalmoparesis (MS-INO; n = 8) showing ocular function responses [velocity-versional dysconjugacy index (VDI)] during whole body heat stress (increase internal temperature ∼0.8°C) and subsequent whole body cooling (return to normothermic baseline). A significant slowing (P < 0.001) of horizontal eye movements (increasing velocity-VDI) was observed in MS patients with INO during whole body heating. However, ocular function was restored to preheating baseline with subsequent whole body cooling. Data are expressed as means ± SD. Reproduced from Davis et al. (15) with permission from Lippincott Williams and Wilkins/Wolters Kluwer Health.