Fig. 2.

A: time course of [Ca²⁺]_i change (Δ[Ca²⁺]_i) before and after restoration of extracellular [Ca²⁺] to 2.5 mM in distal PVSMC perfused with Ca²⁺-free Krebs ringer bicarbonate (KRB) solution containing 10 μM CPA, 1 mM EGTA, and 5 μM nifedipine (Nifed+CPA; n = 8 experiments in 239 cells) and in control cells, which did not receive CPA but were otherwise treated similarly (Nifed; n = 6 experiments in 168 cells). B: average peak change in [Ca²⁺]_i during restoration of extracellular [Ca²⁺] between 15 and 30 min in cells shown in A. *P < 0.0001 vs. cells absent of CPA.