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. 2010 Aug 18;299(5):F1065–F1077. doi: 10.1152/ajprenal.00277.2010

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Fig. 4. — Rhbg expression in intercalated cell-specific Rhbg knockout (IC-Rhbg-KO) mouse kidney. A and B: low-magnification images showing reduced Rhbg immunoreactivity in kidneys of IC-Rhbg-KO mice compared with control (C). C and D: double-immunolabeling in the CCD with antibodies to Rhbg (brown) and H⁺-ATPase (blue) used to characterize cell-specific Rhbg expression in C and IC-Rhbg-KO mice. C: C mice exhibited intact Rhbg expression in both intercalated cells (arrows) and principal cells (arrowheads), with greater immunolabel in intercalated cells. D: IC-Rhbg-KO mice had normal principal cell Rhbg immunoreactivity (arrowheads), but intercalated cells lacked Rhbg immunolabel (arrows). E and F: Rhbg expression in the OMCD of C and IC-Rhbg-KO mice. Again, basolateral Rhbg immunolabel is absent in intercalated cells (arrows) and intact in principal cells (arrowheads) in IC-Rhbg-KO mice.