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. 2010 Aug 18;299(5):F1065–F1077. doi: 10.1152/ajprenal.00277.2010

Fig. 8.

Fig. 8.

Effect of IC-Rhbg-KO on phosphate-dependent glutaminase (PDG), phosphenolpyruvate carboxykinase (PEPCK), and Rhcg expression. A: immunoblot analysis of PDG and PEPCK expression in the cortex of C and IC-Rhbg-KO mice. Diet: C or A. B: quantification of PDG protein expression. Cortical PDG expression is not significantly different between IC-Rhbg-KO and C mice while on control diet. Acid loading increases PDG expression but PDG expression does not differ significantly between C and IC-Rhbg-KO mice. C: quantification of PEPCK expression. Cortical PEPCK expression is not significantly different between IC-Rhbg-KO and C mice fed control diet. Acid loading increases PEPCK expression, but PEPCK expression does not differ significantly between C and IC-Rhbg-KO acid-loaded mice. D: immunoblot analysis of Rhcg expression in control and IC-Rhbg-KO mice on control diet and after acid loading. E: quantification of Rhcg expression. Rhcg protein expression does not differ between C and IC-Rhbg-KO mice on control diet. Metabolic acidosis increases Rhcg expression, but there is no difference in Rhcg expression between acid-loaded C and IC-Rhbg-KO mice.