Fig. 5.

Blockade of murine CaCC by the calmodulin inhibitor W-7. A: pericytes were held at −80 mV and sequentially depolarized to +70 mV for 1,000 ms at 10-s intervals (inset). Concatenated examples (interpulse intervals omitted) of currents elicited during depolarizations at baseline, during exposure to W-7 (30 μM), and at washout are shown. B: end-pulse current as a function of time during exposure to W-7 followed by the CaCC inhibitor niflumic acid (100 μM, Nif A). Inhibition by either blocker was reversible. C: summary of end-pulse CaCC before, during, and after exposure to W-7 (n = 7). *P < 0.05 vs. baseline.