Table 1.

Summarized findings of the present study

	Fetal		Adult
Finding	Normoxic*	Hypoxic	Normoxic*	Hypoxic
PKC-induced contractility	+	+	++	+++
ERK1/2 inhibition-mediated increase in PKC-induced contractility	+	+	+	−
Basal PKC	++	++	++	+++
Activated PKC	++	++	++	+
PKC-induced total ERK1/2 phosphorylation	+++	+++	+++	+++
PKC-induced ERK1 phosphorylation	+	+	+++	+
PKC-induced ERK2 phosphorylation	++	+++	++	+
ROCK inhibition-mediated decrease in PKC-induced contractility	+	−	−	−
PKC-induced MLC20 phosphorylation sustainability	5 min	2 min	5 min	2 min
PKC-induced CPI-17 phosphorylation*	−	−	+	+

n = 4 for each group. MLC₂₀, 20-kDa myosin light chain.

^*Normoxic data published in Refs. 19 and 20.