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. 2010 Nov 12;5(11):e15486. doi: 10.1371/journal.pone.0015486

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Cox et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Sall4 associates with Sox2 primarily through a region C-terminal to the HMG domain of Sox2. The region N-terminal of the HMG domain of Sox2 also mediates the association between Sox2 and Sall4; whereas, the HMG domain of Sox2 may weakly interfere with the association between Sox2 and Sall4, as indicated by the dashed line. (B) HDAC1 primarily associates with Sox2 through Sox2 amino acids 124 to 180. The dashed line indicates interference of association observed between Flag-Sox2 and HDAC1 by the Sox2-HMG domain. (C) Endogenous HDAC2 (from 293T cells) primarily associates with Flag-Sox2 through the HMG domain of Sox2. (D) Flag-Sox2 associates with GFP-Sox2 through multiple domains.