Table 2.
Performance of BLOODchip version 1.0 versus serology; RhD investigationsa
| Discordant results BLOODchip version 1.0 versus serology | |||
|---|---|---|---|
| Number | genotype (defined by BLOODchip) | BLOODchip | serology |
| a) Data entry errors in serology (3) | |||
| 613 | DVI type II | partial D | RhD+ |
| 3693 | DVI type II | partial D | RhD+ |
| 3527 | weak D type 1 | weak D | RhD- |
| b) Partial D by BLOODchip version 1.0 and RhD+ by serology (5) | |||
| 1993 | DVI type IV | partial D | RhD+ |
| 2824 | DNU | partial D | RhD+ |
| 4154 | DVI type II | partial D | RhD+ |
| 4571 | DVa type 2 (Hus)/DV type 7 | partial D | RhD+ |
| 4676 | DHMi | partial D | RhD+ |
| c) Partial D by BLOODchip version 1.0 and weak D by serology (7) | |||
| 926 | DCS | partial D | weak D |
| 1054 | DVI type II | partial D | weak D |
| 1106 | DVI type II | partial D | weak D |
| 1996 | DVI type IV | partial D | weak D |
| 4654 | DVI type II | partial D | weak D |
| 5317 | DVI type II | partial D | weak D |
| 7632 | DVI type II | partial D | weak D |
| d) Partial D by BLOODchip version 1.0 and RhD– by serology (1) | |||
| 2253 | DIIIc | partial D | RhD- |
| e) Weak D by BLOODchip version 1.0 and RhD+ by serology (6) | |||
| 615 | weak D type 2 | weak D | RhD+ |
| 3277 | RHD (M295I)_possible ht Del/weal type 11 | : Dweak D | RhD+ |
| 3586 | weak D type 2 | weak D | RhD+ |
| 4450 | weak D type 3 | weak D | RhD+ |
| 4978 | weak D type 4 | weak D | RhD+ |
| 7284 | weak D type 4 | weak D | RhD+ |
| f) Del by BLOODchip version 1.0 and RhD+ by serology (1) | |||
| 2874 | RHD (L153P) | Del | RhD+ |
| g) Del by BLOODchip version 1.0 and weak D by serology (1) | |||
| 6769 | RHD (M295I)_ Del | Del | weak D |
| Discrepancies against BLOODchip version 1.0 | |||
| Number | genotype (defined by BLOODchip) | BLOODchip | serology |
| RhD+ by BLOODchip version 1.0 and weak D by serology (2) | |||
| 3694 | 'Apparently non-negative' | RHD | weak D |
| 3695 | 'Apparently non-negative' | RHD | weak D |
aThe table shows the results of analysing 3,000 samples with BLOODchip version 1.0 and comparing the results directly with serology. The only two discrepant samples against BLOODchip (bottom section of table) are most likely novel RhD variants and are currently undergoing DNA sequence analysis. Data from Shinnapapa et al. (manuscript in preparation).