Fig. 2. Enrichment of repressive marks are lost with age, especially in pericentric regions and 4^th chromosome.

(A) Comparison of H3K9me3 marks averaged over 50 kb regions for each chromosome at 10 days (top) and 40 days (bottom). The data are expressed as a heat map with brighter colors representing greater binding of H3K9me3 in that region: the greatest signal changes occur at the pericentric heterochromatin of chr 2L, 2R, and 3L (marked with blue bounding box), and chr 4. (B) Comparison of HP1 signal at 10 days (top) and 40 days (bottom). (C) Two color heat map comparing relative signal of H3K9me3 (red) and HP1 (green). Areas of high H3K9me3 appear red, high HP1 green, high in both marks yellow, and low in both marks black. All chromosomes are drawn to relative scale except chr 4, which is enlarged.