. Author manuscript; available in PMC: 2011 Dec 5.

Published in final edited form as: Chem Biol Interact. 2010 Aug 7;188(3):376–385. doi: 10.1016/j.cbi.2010.07.025

Table 2.

In vitro IC₅₀ of selected inhibitors against GALK

Compound	IC₅₀(μM)	LD₅₀(μM)	Compound	IC₅₀(μM)	LD₅₀(μM)	Compound	IC₅₀(μM)	LD₅₀(μM)	Compound	IC₅₀(μM)	LD₅₀ (μM)
1	0.7	<10	10	6.5	>100	19	N/A^*		28	20	10
2	>40	N/T^**	11	33.3	50	20	25	<10	29	N/A^*
3	10.5	10	12	N/A^*		21	18.5	10	30	21.1	50
4	1.5	<10	13	33.3	100	22	30	10	31	21	20
5	12	10	14	27.1	50	23	11.5	100	32	20.3	>100
6	16.5	50	15	>40	N/T^**	24	6.3	<10	33	N/A^*
7	N/A^*		16	30	50	25	>40	N/T^**	34	N/A^*
8	24	50	17	12.1	50	26	19.3	10
9	5.2	10	18	12.5	60	27	32	50

Not commercially available for study.

^**

Not tested