Table 1.
Fatty acid composition of serum phospholipids (weight %) from patients with familial adenomatous polyposis before and after treatment with Rofecoxib
| Placebo group | Rofecoxib group | 95% CIb | |||||||
|---|---|---|---|---|---|---|---|---|---|
| At baseline n = 17 | After intervention n = 15 | P valuea | At baseline n = 18 | After intervention n = 15 | P valuea | ||||
| P valueb,c | Lower | Upper | |||||||
| Fatty acids (weight %) in serum phospholipids | |||||||||
| Myristic acid | 0.1 ± 0.01 | 0.8 ± 0.2 | <0.01 | 0.01 ± 0.01 | 0.6 ± 0.2 | <0.01 | 0.02 | −0.4 | −0.04 |
| Palmitoleic acid | 0.3 ± 0.4 | 0.6 ± 0.3 | <0.001 | 0.4 ± 0.3 | 0.6 ± 0.3 | 0.007 | 0.9 | −0.2 | 0.2 |
| ALA | 0.1 ± 0.1 | 0.2 ± 0.2 | <0.01 | 0.01 ± 0.04 | 0.2 ± 0.2 | <0.01 | 0.4 | −0.1 | 0.1 |
| Eicosaenoic acid | 0.1 ± 0.1 | 0.01 ± 0.01 | 0.9 | 0.01 ± 0.01 | 0.1 ± 0.1 | <0.01 | 0.01 | 0.02 | 0.1 |
| Eicosadienoic acid | 0.2 ± 0.5 | 0.3 ± 0.3 | 0.3 | 0.1 ± 0.2 | 0.3 ± 0.2 | <0.001 | 0.7 | −0.3 | 0.4 |
| EPA | 1.7 ± 1.0 | 1.9 ± 0.9 | 0.6 | 1.5 ± 0.8 | 1.9 ± 0.8 | 0.03 | 0.6 | −0.6 | 0.9 |
| DHA | 11.2 ± 2.7 | 9.9 ± 2.2 | 0.02 | 11.0 ± 3.2 | 9.9 ± 1.9 | 0.03 | 0.8 | −1.4 | 1.9 |
| Palmitoleic/palmitic acid | 0.01 ± 0.1 | 0.02 ± 0.1 | <0.001 | 0.01 ± 0.1 | 0.1 ± 0.1 | 0.004 | 0.9 | −0.1 | 0.1 |
| EPA/DHA | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 | 0.1 ± 0.1 | 0.2 ± 0.1 | 0.006 | 0.8 | −0.1 | 0.1 |
Results are presented as mean ± standard deviation
a P value: between baseline and intervention
b P value: treatment effect: difference between end value and start value
cThe results for palmitic acid, stearic acid, oleic acid, LA, AA, SAT, MUFA, PUFA, sum omega-3 fatty acids, sum omega-6 fatty, omega-3/omega-6 fatty acids acids, sum omega-9 fatty acids, LA/AA, EFA indexd, PUFA/(SAT + MUFA) and sum omega-7 and omega-9 fatty acids were not significant (all subjects) (data not shown in Table). After exclusion of the patients that were compliant for less than 8 months (n = 4, 50% placebo), similar treatment effects were found for the same fatty acids: myristic acid (P = 0.02, 95% CI = −0.4; −0.1) and eicosaenoic acid (P = 0.02, 95% CI = 0.01; 0.1), and additionally for EFA index (P = 0.01, 95% CI = −0.9;−0.1), PUFA/(SAT + MUFA) (P = 0.02, 95% CI = −0.3; −0.1), and sum omega-7 and omega-9 fatty acids (P = 0.01, 95% CI = 1.3; 8.1)
dEFA index: (sum omega-3 fatty acids and sum omega 6 fatty acids) / (sum omega-7 and omega-9 fatty acids)