Table 2.
Nonalcoholic steatohepatitis Clinical Research Network system for scoring activity and fibrosis in nonalcoholic fatty liver disease (modified from[54])
| Steatosis grade (S) | Lobular inflammationa (L) | Hepatocyte ballooning (B) |
| 0: < 5% | 0: None | 0: None |
| 1: 5%-33% | 1: < 2 | 1: Few ballooned cells |
| 2: 34%-66% | 2: 2-4 | 2: Many ballooned cells |
| 3: > 66% | 3: > 4 |
a
Counted in 20 × fields. Nonalcoholic fatty liver disease Activity Score: S + L + B (range 0-8). Stage of fibrosis (Fibrosis score): 0: None; 1: 1a, mild, zone 3 perisinusoidal fibrosis, 1b, moderate, zone 3 perisinusoidal fibrosis, 1c, portal/periportal fibrosis only; 2: Zone 3 perisinusoidal fibrosis and portal/periportal fibrosis; 3: Bridging fibrosis; 4: Cirrhosis, probable or definite.