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Effect of H2AX mutations on IR-induced focus formation of MDC1 and 53BP1. H2AX−/− ES cells were transiently transfected, in parallel, with mammalian expression vectors encoding H2AX Y142 mutants or ubiquitination mutant 5KR and then treated with 10 Gy of IR. Cells were immunostained for HA-H2AX species, MDC1 and 53BP1. DAPI staining is also shown.
