Figure 2.

Network structure of the main catabolic pathways of glucose-fed yeast cells. The primary reactions include membrane transport and glycolytic and fermentative reactions, as well as extracellular reactions. The black and blue reactions constitute the reactions included in Model-0. The reactions in red constitute the additional reactions included in Model-1. Dashed gray arrows indicate normally important catabolic reactions that we assume to be inactive under the experimental conditions and which therefore are excluded in the models. Enzymatic names corresponding to the model in sections S8 and S9 in the Supporting Material are shown in green. Subscript x denotes extracellular species.