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. 2010 Nov 17;99(10):3412–3419. doi: 10.1016/j.bpj.2010.09.026

Figure 1.

Figure 1

A cartoon representation of GK with the pulling directions tested experimentally by Tseng et al. (48) The color coding of the protein is according to the domain definitions of Hible et al. (67) The GMP and ATP binding sites are located at the GMP/CORE and CORE/LID interfaces, respectively. The arrow indicates the direction of the opening/closing transition, which constitutes the first mode of motion of the protein. The images in this figure and in the upper part of Fig. 5 were prepared using visual molecular dynamics (71).