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Membrane properties of SM analogs. (A) Area per lipid molecule (cholesterol excluded). (B) Membrane thickness measured as phosphate-phosphate (P-P) distance. (C) Order parameter SCD averaged over the sphingosine chain. (D) Tilt of cholesterol molecule as measured from the (outgoing) bilayer normal. The simulated systems were composed of pure SM analogs and SM analogs with 20 mol % cholesterol.
