Figure 4.

Inhibition of entry of wild-type and gp41 N43D mutant HIV into primary CD⁴⁺ T cells by SQ435 (A and B) and Enfuvirtide (C). Replication (% of control) was determined by single-round infectivity assay with GFP-encoding recombinant HIV. Individual donors illustrated with unique symbols and separate curves to illustrate the donor-to-donor variability in potency. (Solid symbol) Wild-type virus. (Open symbol) N43D mutant. (Dashed lines) Aggregate IC₅₀ curve across all donors, and two different dash styles distinguish the two viruses used.