Figure 5.
Inhibition of entry of HIV bearing five different envelopes into primary CD4+ T cells by SQ435 (A) and Enfuvirtide (B). Envelopes tested include CXCR4-tropic HXB2, two CCR5-tropic reference envelopes YU-2 and SF162, and two clinically isolated CCR5-tropic envelopes C98v1e4 and C109v1e4. Replication (% of control) was determined by a single-round infectivity assay with GFP-encoding recombinant HIV. Each envelope isolate is illustrated with a unique symbol and separate curve. (Dashed lines) Aggregate IC50 curve across all clinical isolates.