Figure 3.

Correlation between permeability coefficients α_A and α_G with SF of stem cell and z_max. (A) (Blue) Permeability coefficients α_A and α_G in Eq. 8 (log scale) versus stratification factor (SF) defined in Eq. 9; (Green) permeability coefficients versus epithelium thickness. (B) Coefficients α_A and α_G versus SF with a fixed epithelium thickness. In the simulations, z_max is fixed to be 0.02 cm, which can be achieved by adjusting one of γ_A and γ_G. (C) α_A = α_G is varied from 10 to 100 with different binding rates (k_af = k_gf = 0, 0.01, 0.1). In these simulations, the epithelium thickness z_max is fixed to be 0.02 cm by adjusting γ_A. (D) Cell distributions with three sets of parameters with different coefficient values of α_A and α_G. The parameters associated with the above simulations are listed in Table S1 and Table S2.